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KMID : 1011420170220020097
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Journal of Korean Ophthalmic Optics Society
2017 Volume.22 No. 2 p.97 ~ p.103
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Correlation between Tear Proteins Deposition and Oxygen Transmissibility of Soft Contact Lenses
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Lee Ji-Young
Lee Jun-Il
Kim So-Ra
Park Mi-Jung
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Abstract
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Purpose: In this study, the effect of lysozyme, albumin and lobulin on the oxygen transmissibility of soft contact lenses was investigated.
Methods: The amount of deposited protein was measured after exposing etafilcon A lens (high water content, ionic) and hilafilcon B lens (high water content, non ionic) to lysozyme, albumin and globulin solutions, respectively and the oxygen transmissibility of those lenses was measured by employing the polarographic method.
Results: The amount of lysozyme deposition in etafilcon A lens was greater than 100 times compared with albumin and globulin depositions. The correlation between protein eposition and decrease in oxygen transmissibility was shown in all protein solutions, and the decrease of oxygen transmissibility caused by a large amount of lysozyme deposition was greater when the exposure time was same. However, when the same amount of tear protein was deposited, the decrease of oxygen transmissibility caused by globulin was the largest. The deposited amounts of lysozyme, albumin, and globulin in hilafilcon B lens were almost same and much smaller compared with those in etafilcon A lens, and the change in oxygen transmissibility was not significant. Hilafilcon B lens also had a correlation between the amount of globulin deposition and decrease in oxygen transmissibility.
Conclusions: Therefore, it is suggested that the consideration of the amount of deposited protein in the soft contact lens as well as the type of deposited protein is necessary since the difference in oxygen transmissibility according to soft contact lens materials is related to the amount of protein deposition in the lens and globulin has the greatest effect on oxygen transmissibility.
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KEYWORD
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Etafilcon A, Hilafilcon B, Oxygen transmissibility, Tear protein, Albumin, Globulin, Lysozyme
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